找到了!GWAS确定44种重度抑郁症遗传因子|英语流利说
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据美国趣味科学网报道,一个由200多名科学家组成的全球联合研究团体鉴别出44种基因变体(即基因发生的微小变化),其中每种基因变体都会在较小程度上影响一个人患抑郁症的风险。其中30种基因变体是首次被鉴别出来。
研究人员希望这项发现能为研制新的、多样化的抗抑郁疗法铺平道路。世界卫生组织称,抑郁症通常会造成严重伤害,该病影响着全世界近15%的成年人。仅有约一半的患者对药物和心理疗法等现有治疗手段反应良好。
#'Gene map for depression' sparks hopes of new generation of treatments#
#抑郁症基因#
Scientists have raised hopes for more effective treatments for depression, a condition that affects over 300 million people globally, after mapping out the genetic foundations of the mental disorder in unprecedented detail.
In the world’s largest investigation into the impact of DNA on the mental disorder, more than 200 researchers identified 44 gene variants that raise the risk of depression. Of those, 30 have never been connected to the condition before.
By tripling the number of gene regions linked to depression, scientists now hope to understand more about why the disorder strikes some but not others, even when they have similar life experiences. The work could also help in the search for drugs to treat the condition which affects as many as one in four people over a lifetime.
- 参考译文
科学家们以前所未有的细节绘制出了精神疾病的基因遗传基础,这让更有效的治疗抑郁症有了希望。全球范围内有超过3亿人罹患此病。
在世界上最大规模的关于DNA对精神障碍影响的调查中,超过200名研究人员鉴别出44种能增加患抑郁症风险的基因变体,其中有30种是首次被鉴别出来。
通过将与抑郁症相关的基因区域增加两倍,科学家们现在希望能更多地了解为什么这种疾病会影响到某一部分人,即使他们和其他人有相似的生活经历。这项研究还可以帮助寻找治疗抑郁症的药物,在人的一生中,每四个人中就会有一个人受抑郁症影响。
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