ACC 2021精彩抢先看！5场LBCT，3场特色临床研究，都有哪些看点？
5月15日至17日，2021年美国心脏病学会（ACC）年会将在线上拉开帷幕。日前，ACC官网列出了本次年会上即将公布的临床试验，包括5个Late-Breaking Clinical Trials专场和3个特色临床研究专场，共42项研究。
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ACC/JACC LBCT I
时间：5月15日，9:00 a.m. – 10:00 a.m. ET 研究1：PARADISE-MI: Prospective Arni Versus Ace Inhibitor Trial To Determine Superiority In Reducing Heart Failure Events After Myocardial InfarctionPARADISE-MI前瞻性试验：探究血管紧张素受体脑啡肽酶抑制剂（ARNI）较血管紧张素转换酶抑制剂（ACEI）在减少心梗后心衰事件方面的优势 研究2：ADAPTABLE Study: Aspirin Dosing: A Patient-centric Trial Assessing Benefits And Long-term Effectiveness TrialADAPTABLE试验：评估不同剂量阿司匹林的获益和长期疗效的以患者为中心的研究 研究3：LAAOS III: The Left Atrial Appendage Occlusion Study IIILAAOS III试验：左心耳封堵研究III 研究4：Randomized Atlantis Trial: Oral Anti-xa Anticoagulation After Trans-aortic Valve Implantation For Aortic StenosisATLANTIS随机试验：经主动脉瓣膜植入术治疗主动脉瓣狭窄后口服抗Xa因子进行抗凝治疗特色临床研究 I
时间：5月15日，12:15 – 1:30 p.m. ET 研究1：Results from the EXPLORER-HCM Randomized Clinical Trial: Health Status Benefits of Mavacamten In Patients with Symptomatic Obstructive Hypertrophic CardiomyopathyEXPLORER-HCM随机对照试验：Mavacamten治疗对症状性梗阻性肥厚型心肌病患者健康状况的益处 研究2：A Report From the NCDR LAAO Registry: One-year Clinical Outcomes Following Watchman Transcatheter Left Atrial Appendage Occlusion For Stroke Prevention In Patients With Atrial FibrillationNCDR LAAO注册中心的报告：使用Watchman封堵器进行左心耳封堵预防房颤患者卒中的1年随访临床结局 研究3：Analysis Of Clinical Outcomes in the Node-301 Trial: Etripamil Nasal Spray Relieves Symptoms And Reduces Emergency Room Interventions In Patients With Paroxysmal Supraventricular Tachycardia (PSVT)NODE-301试验结果分析：在阵发性室上性心动过速（PSVT）患者中，应用鼻喷雾剂依曲帕米（Etripamil）有利于缓解症状，减少急诊室干预 研究4：Atlantis 4d Computed Tomography Substudy: Valve Thrombosis After Transcatheter Aortic-valve ReplacementATLANTIS 4D计算机断层扫描子研究：经导管主动脉瓣置换术后的瓣膜血栓形成 研究5：30-day Results of the Triscend Study: Transfemoral Tricuspid Valve Replacement In Patients With Tricuspid RegurgitationTRISCEND试验的30天结果：在三尖瓣反流患者中进行经股动脉三尖瓣置换术 研究6：Results From the Twilight Study: Sex-Specific Outcomes In High-Risk Patients Receiving Ticagrelor With Or Without Aspirin After Percutaneous Coronary InterventionTWILIGHT试验结果：在PCI后高危患者中，进行替格瑞洛联合/不联合阿司匹林治疗的性别特异性结局ACC/JACC LBCT II
时间：5月16日，8:00 a.m. – 9:30 a.m. ET 研究1：Effects Of Dapagliflozin On Prevention Of Major Clinical Events And Recovery In Patients With Respiratory Failure Due To COVID-19 - Main Results From The DARE-19 Randomized TrialDARE-19随机对照试验的主要结果：达格列净对COVID-19所致呼吸衰竭患者主要临床事件和康复疗效的影响 研究2：VOYAGER PAD Trial: Reductions In Total Ischemic Events With Rivaroxaban In Patients With Symptomatic Pad After RevascularizationVOYAGER PAD试验：在有症状的外周动脉疾病（PAD）患者血运重建后，进行利伐沙班治疗对总缺血事件减少的作用 研究3：STAMPEDE Trial: Surgical Versus Medical Treatment Of Type 2 Diabetes: 10-year Results of the Stampede Randomized Clinical TrialSTAMPEDE随机对照试验的10年结果：2型糖尿病患者中，外科手术 vs药物治疗 研究4：REHAB-HF Trial: A Novel Physical Rehabilitation Intervention For Older Patients With Acute Decompensated Heart FailureREHAB-HF试验：在老年急性失代偿性心衰患者中，进行新型物理康复干预治疗 研究5：Relationship Between Omega-3 Fatty Acid Levels And Major Adverse Cardiovascular Outcomes In Patients With High Cardiovascular Risk在心血管高风险患者中，Omega-3脂肪酸水平与主要不良心血管事件之间的关系 研究6：PRADA Trial: Prevention Of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy: Long-term Follow-up Of A 2 X 2 Factorial, Randomized, Placebo-controlled, Double-blind Clinical Trial Of Candesartan And MetoprololPRADA试验：在辅助性乳腺癌治疗期间心功能不全的预防：对坎地沙坦和美托洛尔的2X2析因、随机、安慰剂对照、双盲临床试验的长期随访结果ACC/JACC LBCT III
时间：5月16日，10:45 a.m. – 12:15 p.m. ET 研究1：The FLOWER-MI Randomized Trial: Fractional Flow Reserve-guided Versus Angio-guided Multivessel Revascularization In ST-Elevation Myocardial Infarction PatientsFLOWER-MI随机对照研究：在ST段抬高型心肌梗死（STEMI）患者中，进行血流储备分数（FFR）引导和血管造影引导的多支血管血运重建术的比较 研究2：A Prospective, Multicenter, Randomized, Open-label Trial To Compare Efficacy And Safety Of Clopidogrel Versus Ticagrelor In Stabilized Patients With Acute Myocardial Infarction After Percutaneous Coronary Intervention一项前瞻性、多中心、随机、开放标签的临床试验：在稳定的急性心梗患者进行PCI后，比较氯吡格雷与替格瑞洛的疗效和安全性 研究3：Host Exam Randomized Controlled Trial: Aspirin Vs. Clopidogrel During Chronic Maintenance Monotherapy After Percutaneous Coronary InterventionHOST-EXAM随机对照试验：在PCI后，比较进行阿司匹林和氯吡格雷单药治疗的长期疗效 研究4：Late Outcomes Of A 1-hour High Sensitivity Troponin T Protocol In Suspected Acute Coronary Syndromes: A Randomized Clinical Trial在疑似急性冠脉综合征（ACS）患者中，进行1h高敏感肌钙蛋白T检测的随机临床试验的最新结果 研究5：Randomized Sham-controlled RADIANCE-HTN TRIO Trial: Endovascular Ultrasound Renal Denervation To Treat Hypertension Resistant To A Fixed Dose Triple Medication PillRADIANCE-HTN TRIO随机假对照试验：血管内超声下去肾神经支配术治疗对固定剂量三联药物耐药的高血压特色临床研究 II
时间：5月16日，2 – 3:30 p.m. ET 研究1：SAFE-PAD Study: Initial Report From the Safety Assessment Of Femoropopliteal Endovascular Treatment With Paclitaxel-coated Devices StudySAFE-PAD研究：使用紫杉醇涂层装置进行股腘动脉血管内治疗的安全性评估的初步报告 研究2：One-year Follow-up of the Reality Randomized Clinical Trial: Effect Of A Restrictive Vs Liberal Blood Transfusion Strategy On Major Cardiovascular Events Among Patients With Acute Myocardial Infarction And AnemiaREALITY试验1年随访结果：在急性心梗合并贫血的患者中，对比限制性输血与自由输血策略对患者主要心血管事件的影响 研究3：World Alliance Societies Of Echocardiography COVID Study: Human Vs Machine Learning-based Echocardiography Analysis As Predictor Of Outcomes In Acute Covid-19 Patients世界超声心动图联盟学会（WASE）COVID试验：在急性COVID-19患者中，将基于人和计算机的超声心动图分析作为患者预后预测指标的对比 研究4：Coalition ACTION Trial: Randomized Clinical Trial To Evaluate A Routine Full Anticoagulation Strategy In Patients With Coronavirus Infection (SARS-CoV-2) Admitted To HospitalCOALITION ACTION试验：在新冠病毒感染住院患者中，评估常规进行全面抗凝策略的随机临床试验 研究5：Inspiration-S Double Blind Randomized Controlled Trial: Atorvastatin Versus Placebo In Critically-ill Patients With Covid-1INSPIRATION-S双盲随机对照试验：在危重COVID-19患者中，对比阿托伐他汀与安慰剂的疗效 研究6：ACC 2020 Well Being Study: Impact of COVID-19 on the Global Cardiovascular WorkforceACC 2020 WELL BEING研究：COVID-19对全球心血管医生职业状态的影响LBCT Ⅳ
时间：5月17日，8:00 a.m. – 9:30 a.m. ET 研究1：Benefits Of Sodium Glucose Co-transporter-1/2 Inhibition With Sotagliflozin Across The Full Spectrum Of Ejection Fraction, Including Heart Failure With Preserved Ejection Fraction在不同射血分数的心衰（包括射血分数保留的心衰）患者中，进行钠-葡萄糖共转运蛋白1/2（SGLT2）抑制剂索格列净治疗的获益 研究2：Primary Results of the Connect-hf Randomized Clinical Trial: Care Optimization Through Patient And Hospital Engagement Clinical Trial For Heart FailureCONNECT-HF随机试验的主要结果：由患者和医院参与的心衰护理优化临床试验 研究3：Results of the LIFE Trial: Sacubitril/Valsartan (LCZ696) In Patients With Advanced Heart Failure And Reduced Ejection FractionLIFE试验结果：沙库巴曲缬沙坦（LCZ696）在晚期射血分数降低的心衰（HFrEF）患者中的作用 研究4：Pirfenidone In Heart Failure With Preserved Ejection Fraction吡非尼酮治疗射血分数保留的心衰（HFpEF） 研究5：Secondary Analysis From GALACTIC-HF: Impact Of Ejection Fraction On The Therapeutic Effect Of Omecamtiv Mecarbil In Patients With Heart Failure And Reduced Ejection FractionGALACTIC-HF试验的二次分析：在HFrEF患者中，探究射血分数对omecamtiv mecarbil治疗效果的影响LBCT Ⅴ
时间：5月17日，10:45 a.m. – 12:15 p.m. ET 研究1：Therapeutic Hypothermia Following Out-Of-Hospital Cardiac Arrest: A Randomized Trial Comparing Mild And Moderate Therapeutic Hypothermia院外心脏骤停的低温治疗：比较轻度和中度低温治疗的随机对照试验 研究2：Prague OHCA Study: Hyperinvasive Approach In Refractory Out-of-Hospital Cardiac Arrest: An Open-label Randomized Controlled TrialPRAGUE OHCA开放标签、随机试验：难治性院外心脏骤停患者的侵入性治疗 研究3：RAFT-AF: A Randomized Ablation-based Atrial Fibrillation Rhythm Control Versus Rate Control Trial In Patients With Heart Failure And High Burden Atrial FibrillationRAFT-AF随机试验：在心衰和房颤高负荷患者中，对比基于消融的房颤心律控制和心率控制的疗效 研究4：Acute Alcohol Consumption And Discrete Atrial Fibrillation Events急性饮酒和随机房颤事件 研究5：Finerenone And New Onset Of Atrial Fibrillation Or Flutter In Patients With Chronic Kidney Disease And Type 2 Diabetes在慢性肾病和2型糖尿病患者中，Finerenone应用与新发房颤或房扑的关系特色临床研究 Ⅲ
时间：5月17日，12:30 – 1:45 p.m. ET 研究1：One-year Results of the American College Of Cardiology Global Heart Attack Treatment Initiative: Worldwide ST-elevation Myocardial Infarction CareACC全球心脏病发作治疗倡议的1年结果：全球STEMI护理 研究2：ISCHEMIA Trial: Impact Of Completeness Of Revascularization On Clinical Outcomes In Patients With Stable Ischemic Heart Disease Treated With An Invasive Vs. Conservative StrategyISCHEMIA试验：在稳定型缺血性心脏病患者（介入治疗 vs 保守治疗）中，血运重建完整性对临床结局的影响 研究3：Insights From the ISCHEMIA Trial: Impact Of Completeness Of Revascularization On Quality-of-life In Patients With Stable Ischemic Heart Disease来自ISCHEMIA试验的见解：在稳定型缺血性心脏病患者中，血运重建的完整性对生活质量的影响 研究4：Tailor-Pci Randomized Clinical Trial Follow-up Study: Effect Of Genotype-guided Oral P2y12 Inhibitors Vs Conventional Clopidogrel On Long-term Ischemic Outcomes After Percutaneous Coronary InterventionTAILOR-PCI随机试验：探究PCI后，基因型指导的口服P2Y12受体抑制剂与传统氯吡格雷治疗对长期缺血结局的影响 研究5：Effects Of Interleukin-6 Inhibition With Ziltivekimab On Biomarkers Of Inflammation Among Patients At High Risk For Atherosclerotic Events在动脉粥样硬化事件高危患者中，白细胞介素-6抑制剂Ziltivekimab对炎症生物标志物的影响 资料来源：ACC官网